Movement Disorders - Chorea (MRCP PACES - Neurology)

Chorea is a hyperkinetic movement disorder characterised by brief, irregular, unpredictable, non-rhythmic movements that appear to flow from one part of the body to another. It develops when basal-ganglia dysfunction reduces the normal suppression of unwanted motor activity. In this video, we simplify the clinical features and pathophysiology of chorea, including the role of the indirect basal-ganglia pathway. We also compare chorea with athetosis, ballismus, dystonia, tremor, cerebellar dysfunction, and sensory ataxia to help you recognise different abnormal movement patterns in clinical practice and MRCP examinations. We will cover: Normal control of movement by the basal ganglia, cerebellum, and sensory feedback The athetosis–chorea–ballismus spectrum How to differentiate chorea from dystonia and tremor The indirect basal-ganglia pathway Why reduced indirect-pathway activity causes choreiform movements Clinical features of chorea Motor impersistence, including milkmaid grip and darting tongue The characteristic gait associated with chorea Common causes, including Huntington disease, Sydenham chorea, Wilson disease, stroke, autoimmune disease, metabolic disorders, and medications A practical diagnostic approach Basic management and symptomatic treatment The roles of VMAT2 inhibitors and dopamine receptor blockers This video is designed for medical students, MRCP candidates, junior doctors, and anyone trying to understand chorea in a simple, clinically relevant way. Disclaimer: This video is for educational purposes only and is not a substitute for professional medical advice or specialist clinical guidance. #Chorea #Neurology #MRCP #MedicalEducation #MRCPology Hidden YouTube tags box: chorea, chorea explained, chorea MRCP, choreiform movements, hyperkinetic movement disorder, involuntary movements, basal ganglia, indirect basal ganglia pathway, GABAergic medium spiny neurons, globus pallidus external, subthalamic nucleus, globus pallidus internal, thalamic disinhibition, motor impersistence, milkmaid grip, darting tongue, choreic gait, Huntington disease, Huntington chorea, Sydenham chorea, Wilson disease, neuroacanthocytosis, SLE chorea, antiphospholipid syndrome, hemiballismus, ballismus, athetosis, dystonia, tremor, tardive dyskinesia, VMAT2 inhibitors, tetrabenazine, deutetrabenazine, dopamine receptor blockers, movement disorders, Neurology, MRCP revision, medical students, internal medicine, clinical medicine