JCI's Conversations with Giants in Medicine: James Rothman

In the 1970s and '80s, James Rothman of Yale University bucked all advice on how to do scientific experiments and broke open cells in order to study the way that vesicles are transported. His discovery of the machinery that orchestrates the budding, fusion, and transport of vesicles is key to organelle formation, nutrient uptake, and the secretion of most hormones and neurotransmitters in the body. For this work, Rothman shared the 2013 Nobel Prize in Physiology or Medicine.