A New Strategy for Treating Neuropathic Pain

Conventional methods of pain treatment have often proved ineffective in the treatment of neuropathic pain. Here, in an effort to develop a new therapeutic approach, Allan Basbaum and colleagues transplanted immature telencephalic GABAergic interneurons into the adult mouse spinal cord. These transplants integrated into the spinal cord circuitry and reversed the mechanical hypersensitivity produced by peripheral nerve injury. For more details, see Braz et al., Neuron 74(4).