Болезнь Минимальных Изменений (нефротический синдром) лекция

Minimal change disease (lipoid nephrosis, podocyte foot process disease) is the morphological basis for over 70% of cases of nephrotic syndrome in children under 10 years of age and approximately 50% of cases in those over 10 years of age. It can also occasionally be observed in adults. Minimal change nephropathy is associated with the use of certain medications (NSAIDs, penicillins, rifampin, interferon), viral infections, and food allergies (atopy). Under light microscopy, the glomeruli appear normal, sometimes revealing minimal mesangial proliferation. Immunohistochemical examination of kidney biopsies reveals no signs of immune deposits. Glomerular changes are only detectable by electron microscopy and consist of the disappearance of the podocyte foot processes. Most often, the disease has a sudden onset. Massive proteinuria, most often selective, and nephrotic syndrome, a symptom complex that includes massive proteinuria, hypoalbuminemia, hyperlipidemia, and generalized edema, develop. Renal function is generally unaffected. =========================================================================== Gratitude and Support: Sberbank 2202 2062 4437 3028 Tinkoff 5536 9140 7974 6768