Following & Understanding Your Free Light Chain Test Results in Multiple Myeloma

Frank Courjal, PhD, explains free light chains in multiple myeloma and how urine testing is used to measure them. Presented by: Frank Courjal Director, Scientific Affairs The Binding Site Quebec City, Quebec 0:00 Introduction 2:17 Myeloma Canada 3:11 Understanding and Monitoring Free Light Chain results 5:15 The bone marrow is where all the cells of the blood develop 7:51 Plasma cells make antibodies (immunoglobulin) to block bacteria and viruses 9:32 Normal vs Myeloma 11:26 Signs & Symptoms NON SPECIFIC 14:18 Different types of multiple myeloma secrete different products Light Chain Myeloma 17:15 How many myeloma cells are in the bone marrow? 18:03 Separating and Detecting Serum Proteins to Detect Multiple Myeloma 19:48 Detecting the monoclonal protein in the serum of Multiple Myeloma Patients Serum Protein electrophoresis (SPEP) 21:03 Freelite immunoassay: polyclonal antisera to monoclonal proteins 25:07 Sensitivity of SPE at diagnosis 29:07 MM diagnosis 32:01 The short half-life of SFLCs allows rapid response assessment 33:08 Change in iFLC demonstrates response to therapy more rapidly than SPE 35:09 Clonal diversity at relapse 38:37 Light chain escape 39:37 Attaining SCR improves survival 41:13 Why did my Freelite values change so suddenly? 44:20 Understanding Lab Results 46:07 Why does the doctor ask for a urine test ? 48:04 3 Advantages of Freelite vs. urine analysis 50:17 Urine compliance 51:39 Summary Freelite is recommended in International and Canadian guidelines at diagnosis, for monitoring and in prognosis _________ Founded in 2005, Myeloma Canada is the only national patient-focused charitable organization dedicated to addressing the holistic needs of people impacted by multiple myeloma. Guided by its vision of a life uninterrupted by myeloma, it works to improve lives, increase access to optimal care, and advance research toward a cure. For more information, visit: https://www.myeloma.ca #MultipleMyeloma #MyelomaDiagnosis #UrineTests #FreeLightChainTest