New drug can potentially regenerate hearing & treat hearing loss - Dr. Zheng-Yi Chen

In our latest podcast, we speak with Dr. Zheng-Yi Chen, Associate Professor at Harvard Medical School. Dr. Chen is leading the world in the field of hearing and treatments. Currently, there are no drug treatments for hearing loss. Dr. Chen and his team have now developed a potential treatment for treating hearing loss and to regenerate hearing. This can revolutionize the future of how we treat hearing loss. Link to research: https://www.pnas.org/doi/10.1073/pnas... 0:00 - Introduction 1:34 - Causes of hearing loss 3:59- the impact of genes & environmental factors on hearing loss 5:56- the pathways that cause hearing loss 8:06- the impact of hair cells on hearing loss 10:55- Scope of hair cells and regeneration 15:25- steps of the study for regeneration of hair cells 17:27- compounds used for hair cell regeneration 18:21- which of these compounds are FDA approved 19:29- how the animal model was able to regenerate new hair cells using the treatment 22:06- how long did it take to see results for the animal model 23:23- link of hair cells and hearing 24:42- how to deliver the gene therapy into the ear 25:17- what was the ultimate goal of the study, and what is the next goal of the study 26:07- duration of the next phase of the study 28:25- delivery of previous gene therapies into the ear, and how it can influence the way this therapy will be delivered 29:27- how will success be measured and how can it be used in a clinical scenario 33:50- what needs to be seen in the next phase of the study to be successful 35:40- how soon can this potential treatment be available 37:30- will this therapy be a one time treatment or multiple time treatment 39:05- important findings; how hearing loss can be linked to other diseases like dementia 41:41- how are other gene therapies for hearing being administered 42:52- timeline of clinical trials for genetic hearing loss 45:27- Conclusion #hearing #hearingloss #hearinglosstreatment #clinicaltrials #harvard #dementia #genetherapy #regenerativemedicine #doctor #medicine #clinicaltrials