Understanding Post-Transplant Lymphoproliferative Disease (PTLD)

From the 2025 Pediatric Transplant Conference, part of National Pediatric Transplant Week and National Donate Life Month. Chapters: 00:00 PTLD - A survivor's story 06:21 Understanding PTLD - Presentation 51:24 Understanding PTLD - Q&A Post-Transplant Lymphoproliferative Disease (PTLD) is a potential complication following solid organ or hematopoietic stem cell transplantation. This session will provide essential information on PTLD to address the risks, causes, symptoms, diagnostic approaches, and treatment options for pediatric transplant recipients. Our expert physician will discuss the importance of early detection, strategies for prevention, and the latest advancements in PTLD management. For Caregivers and Transplant Recipients: Understanding PTLD Risks: Learn about the factors that increase the risk of developing PTLD, including the type of transplant, immunosuppression regimen, and EBV status. Recognizing Symptoms: Learn to identify potential symptoms of PTLD and understand when to seek immediate medical attention. Diagnostic Procedures: Understand the diagnostic tests used to detect PTLD which include blood tests, imaging studies, and biopsies. Treatment Options: Learn about the various treatment options available for PTLD which include reduction of immunosuppression, antiviral therapy, chemotherapy, and immunotherapy. Emotional Support: Learn about the emotional burden of PTLD and how to access helpful resources. Key Topics Covered: -Risk factors for PTLD in pediatric transplant recipients -Clinical presentation and diagnostic evaluation of PTLD -Treatment strategies for PTLD, including reduction of immunosuppression, antiviral therapy, chemotherapy, and immunotherapy -Monitoring and follow-up care for patients with PTLD -The role of EBV in PTLD development -Current research and clinical trials This session will provide a comprehensive overview of PTLD to empower patients and families with knowledge about the disease to encourage early detection and effective treatment. Presenter: Rosanna Fulchiero, DO, MSCE, pediatric nephrologist at Inova Children's Hospital, Fairfax, Virginia Speakers: Alissa Chrisos, mother to pediatric heart transplant recipient Mary Chrisos, pediatric heart transplant recipient who was hospitalized for PTLD Intro music: "Oh Are Ready (Inst Mix)" by Moby. Used with permission. Outro music: "Cave Canem (Inst Mix)" by Moby. Used with permission.