Underdosing Benzodiazepines for Seizures? | Neurology | #CodeBlueDebrief

👍 Acutely terminating seizures often puts us in a dilemma; too little and underdose, or too much and toxicities. Working along this spectrum requires a general understanding of the guidelines recommendations. It'll also be good for you to understand benzodiazepine pharmacokinetics. Let's review initial benzodiazepine dosing in the treatment of status epilepticus (SE)! Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Donate $5: www.pharmwyze.com//_paylink/AY78_L7r Social Links: links.pharmwyze.com DrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinbox Streaming Platforms: https://pharmwyze.hopp.to/podstreams Patreon: www.patreon.com/pharmwyze Paypal Donation: https://pharmwyze.hopp.to/paypaldonate PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsl... #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #medicalschool #clinicalpearls #nursingschool #pharmacyschool #medicaleducation #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #antibiotics #neurology #patientcase #clinicalmedicine #clinicalpharmacy References Lee, S. Diagnosis and Treatment of Status Epilepticus. J Epilepsy Res. 2020 Dec 31;10(2):45-54. Kapur et al. Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. N Engl J Med. 2019 Nov 28;381(22):2103-2113. Kohl et al. Status epilepticus and benzodiazepine treatment: Use, underdosing and outcome - insights from a retrospective, multicentre registry. Seizure. 2023 Apr;107:114-120. doi: 10.1016/j.seizure.2023.03.020. Silbergleit et al. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia . 2011 Oct;52 Suppl 8(Suppl 8):45-7. Sathe et al. Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial. Acad Emerg Med . 2019 Aug;26(8):940-943. Glauser et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016 Jan-Feb; 16(1): 48–61. Leppik IE et al. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 1983;249:1452–1454. Alldredge BK et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2001;345:631–637.