Chris Masterjohn PhD – Seed Oils, LDL & Mitochondria | TFP #035

In this episode of The Feldman Protocol, how much does mitochondrial energy metabolism shape long-term health outcomes — and what does that mean for how we interpret cardiovascular, immune, and metabolic research? Dave sits down with Chris Masterjohn (PhD) to explore his mitochondrial testing company and what enzyme-complex patterns may reveal about individual nutritional needs, his longstanding model of LDL oxidation and plaque formation, the emerging pressure-based hypothesis in Crohn's disease research, concerns he raises about polyunsaturated fatty acids and long-term trial design, and the state of peer review and research transparency. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/tfp/35` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `   / @realdavefeldman  ` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `  / realdavefeldman  ` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & intro 1:13 – Chris introduces his mitochondrial testing work 3:36 – ATP, LDL receptors & cellular energy 8:32 – Idiosyncratic nutritional needs & CoQ10 case 14:06 – Exercise, longevity & gymnast data 22:18 – Biomechanics, T cell activation & cancer hypothesis 28:43 – Crohn's disease, pressure hypothesis & diet 38:29 – Paleo, Weston Price & dietary history 47:25 – Causal inference, language in research & peer review 58:28 – Dave's early lipid energy model presentation 1:01:33 – Chris's longstanding LDL oxidation model 1:09:04 – Transcytosis, innate immunity & plaque dynamics 1:30:07 – Monogenic FH, Bradford Hill & LDL debate 1:49:14 – The KETO-CTA study & plaque progression data 1:58:15 – Seed oils: history, trial design & oxidative liability 2:24:01 – Short vs. long-term trial evidence on seed oils 2:46:02 – Research incentives, NIH funding & open data 2:54:35 – Audience questions, diet & supplements 3:00:01 – Where to find Chris Masterjohn #FeldmanProtocol #DaveFeldman #ChrisMasterjohn #Mitochondria #LDL #Cholesterol #SeedOils #Atherosclerosis #LipidHypothesis #CrohnsDisease #NutritionScience #PeerReview #MetabolicHealth #CardiovascularResearch #LipidEnergyModel #PUFA #VitaminE #ResearchTransparency #Longevity