Part 1 Impact Of MTHFR Gene Mutation On Health, Histamine and Detox.

Are you trying to understand the MTHFR gene alteration, the genetics behind it, and whether or not you should take methylfolate, how much you should take, et cetera. this video, we're going to break down the MTHFR gene and some key facts that you need to know and understand. Tests you might want to do, how it's connected to detoxification, what it's not connected to, the role of inflammation when you're trying to optimize your MTHFR gene. **MY COURSE ⭐️ : Get real-world troubleshooting and personal guidance to optimize your health through genetics with this comprehensive MTHFR course. http://discover-holistic-health-acade... **MY BOOK 📕 : Skip the common pitfalls and fast-track your journey to optimal health. https://geni.us/y6lNt (Amazon Affiliate Link) 00:00 Introduction to MTHFR Gene Alteration Break down the MTHFR enzyme, some of the key components of the genetics involved, some of the lab testing to do and various other factors like inflammation and vitamin levels. So the MTHFR enzyme sits in the middle of two very important processes, the production DNA base pairs like the double helix and the production and generation of something known as SAMe. the generation of SAMe and the production of DNA base pairs. Now it does get a little more complex as you zoom in and zoom out of this process and see how it goes. connects to other things, but these two functions, you just have to remember are the two outcomes that we're concerned about when it comes to your functioning or lack of functioning in the MTHFR gene. And so how well these two processes are moving along is going to determine whether or not you have certain symptoms and whether or not your lab metrics are looking the way they should. And when we're looking at lab metrics, we're kind of looking at some of the key things surrounding DNA based pair production and SAMe production. . First though, I think we should look at how this fits into the broader context of your health. So, the MTHFR enzyme has broad reaching effects on our health. Through its connection to these two processes that we mentioned, methylation is SAMe and DNA or pyrimidine base pair production has to do with the DNA base pairs. 01:09 Understanding the MTHFR Enzyme and Its Functions 02:15 The Broad Impact of MTHFR on Health 04:30 Exploring the Role of SAMe and DNA Base Pairs 06:55 Addressing MTHFR Alterations: Benefits and Cautions 08:19 Navigating Treatment and Understanding Needs 08:54 Wrapping Up and What's Next And because it sits at the center of these two important processes, methylation, and DNA based pair productions. A lot of health issues may imply that you might have a problem with the MTHFR enzyme, but it's important to keep it in its place too and not overreach in what it can do and what it might be helping you with or not helping you with. So for instance, our bodies have thousands, thousands of different Reactions occurring throughout the day, constantly, even minute to minute, and the methylation process, the enzymes involved with methylation are really just a small part of this totality of enzymes and reactions that are occurring in the body. So we need to keep that in mind as well. Not only is it just one of many different reactions, it's part of a broader signal and signaling systems in our body. All the molecules in our bodies operate independent, each one being a separate signal, but they're also connected. It's like an ecosystem. Similar to how trees produce leaves and those leaves fall, they fertilize the ground, they allow for worms to get the nutrition that they need, which then allow birds a source of sustenance as well. So our bodies too are like a web of interconnections and different directions. With each molecule kind of creating a signal that then goes on to create another signal. We just have to keep in mind that when we're talking about these things, it is just a model and sometimes it's an oversimplification of a much more complex dynamic system so when you have an alteration in the MTHFR enzyme, your body will typically, depending on how severe it is, make less methylfolate, which is needed in order to make the so when we're asking, what does MTHFR enzyme do or how can it benefit us? We're basically asking, what does SAMe do? And of course, there is the DNA base pair aspect of this, which we'll get to as well. But first, what does SAMe actually do for us? How does it help us? So SAMe is one of the main cofactors for a group of enzymes called methyl transferases. And these enzymes transfer a methyl group from one molecule to another, which can turn that molecule on or turn it off. It's known as activation or deactivation of molecules. And there's a bunch of these methyltransferases. There's DNA methyltransferase. There's histamine N methyltransferase, which is responsible for breaking down, eliminating histamine.