Синдром Жильбера

00:00 Introduction 00:40 Bilirubin Metabolism in the Body 03:00 Gilbert's Syndrome - Definition, Epidemiology 06:15 Pathogenesis, Clinical Features 08:18 Diagnosis 10:41 Benefits 11:50 Medications and Therapies that Inhibit UGT1A1 14:15 UGT1A1 Inducers 15:20 Treatment and Prevention The new webinar from the Hippocrates Project is dedicated to Gilbert's syndrome, a genetic "feature" that can be both a challenge and an unexpected benefit for patients. Key Sections: 1. Basics of the Syndrome: Cause: UGT1A1 gene defect → UDP-glucuronyl transferase enzyme deficiency → accumulation of indirect bilirubin. Epidemiology: 5-12% of the population, men are affected 10 times more often (the role of testosterone). 2. Clinical presentation and diagnosis: Symptoms: Intermittent jaundice, fatigue, abdominal pain. Triggers: Fasting, stress, alcohol, infections, medications (NSAIDs, levothyroxine). Diagnosis: Genetic testing, niacin tests, exclusion of other pathologies. 3. Paradoxes of the syndrome: Benefits: Long lymphocyte telomeres, reduced risk of cardiovascular disease and type 2 diabetes. Risks: Risk of toxicity from medications (HIV therapy, oncology) and plant extracts (milk thistle, garlic). 4. Treatment and Prevention: UGT1A1 gene inducers: Cruciferous vegetables, whole grains, coffee. Therapy: Avoiding triggers, phenobarbital (with caution), phototherapy (limited). Practical Value: Learn how to detect Gilbert's syndrome. Learn how to adjust therapy when prescribed dangerous medications (oncology, HIV). Understand why some patients with Gilbert's syndrome do not require aggressive therapy. Join us to stay up-to-date with new, useful materials for your practice. Speaker: • Mikail Akhmedovich Magerramov, second-year resident, Department of Therapy, Clinical Pharmacology, and Emergency Medical Care, Russian University of Medicine, Ministry of Health of the Russian Federation Watch live broadcasts on our website https://ambdoc.ru Learn more about medicine and the work of the "Ambulatory Doctor" society through social media. Join our communities: VKontakte https://vk.com/ambdoc Telegram https://t.me/ambulatory_doctor YouTube    / Амбулаторныйврач   You can find more recommendations from Professor A.L. Vertkin on his personal pages: Professor Vertkin's Telegram channel https://t.me/arkadyvertkin