Synthesis of Amines | 22.3 Organic Chemistry

Chad provides a comprehensive lesson on the synthesis of amines. This begins with the review of several reduction reactions including the reduction of nitro compounds, nitriles, azides and amides using LiAlH4. But several new syntheses are presented as well including the Hofmann Rearrangement (including the full mechanism), Curtius Rearrangement, and the Schmidt reaction which are all very similar. The Gabriel synthesis for primary amines is also covered as well as why it is necessary and then finally reductive amination is covered which involves the formation of imines and enamines which are then selectively reduced to their corresponding amines. I've created a general chemistry page that organizes all my videos by chapter - just an easier way for you to watch my YouTube videos. Check it out at https://www.chadsprep.com/chads-gener... If you want all my study guides, quizzes, and practice exams, check out my premium course at https://www.chadsprep.com/organic-che... 00:00 Lesson Introduction 00:35 Reduction of Nitro Compounds, Nitriles, and Azides with LiAlH4 01:51 Reduction of Amides with LiAlH4 02:08 Hofmann Rearrangement (including mechanism) 09:29 Curtius Rearrangement 11:32 Schmidt Reaction 12:11 Gabriel Synthesis 19:01 Reductive Amination https://www.chadsprep.com/ #organicchemistry #organicchemistrytutorial