Demystifying GC Method Development | Troubleshooting Tailing Peaks

👉 Get the Chromatography Demystified Mini-course with a free Axion Lite membership. https://courses.axionlabs.com/course/... Peak tailing is one of the most common problems in GC method development—and one of the most misunderstood. In this video from the Chromatography Demystified series, Dr. Lee Polite walks through a real troubleshooting scenario where some peaks tail badly while others look perfectly symmetrical. That contrast tells us something important: the column installation is fine, but adsorption is happening somewhere else in the system. You’ll learn: -How to recognize adsorption-driven peak tailing -Why selective tailing often points to the inlet, not the column -How a dirty liner and gold seal can distort peak shape -When “hot” inlet maintenance is acceptable during troubleshooting -How to use peak symmetry values to confirm the fix Rather than changing the method blindly, this video shows how simple inlet maintenance—replacing the liner and gold seal—can dramatically improve peak symmetry, especially for sensitive compounds like alcohols. This is practical, instrument-level troubleshooting that every GC user should understand, whether you’re developing a new method or maintaining an existing one. 👉 Watch Part 1: GC Method Development Explained    • Demystifying GC Method Development   👉 Watch Part 3: GC Method Development - When to Use a Different Column    • Demystifying GC Method Development - When ...   #analyticalchemistry #axionlabs #chromatography #chemistryeducation #chromatographytraining #gaschromatography