PolyBio Fall 2025 Symposium

Please note that many speakers are featuring unpublished, pilot data. The data should be taken in context that it may change over time as more samples are analyzed, and projects are finalized. 0:00: Amy Proal--An overview of PolyBio’s complex chronic illness research & clinical trials program 10:01: Nicholas Huot--SARS-CoV-2 persistence: a focus on natural killer cell & macrophage dynamics 24:55: David Price--Mapping lung tissue correlates of breathlessness in Long COVID 42:00: Michael Van Elzakker--Long COVID & ME/CFS neuroinflammation and neutrophil function 53:08: Luane Spamer--Development of a Point-of-Care Microclot Detection and Characterization Device 1:03:21: Marcus Buggert--SARS-CoV-2 gut and lymphoid pathology, plus Long COVID longitudinal study 1:16:53: Michela Locci--Lymph node immune responses in Long COVID 1:27:40: Sara Cherry--Long COVID: Defining the viral RNA reservoir in the gastrointestinal tract 1:37:02: Christopher DuPont--An update on the biopsy and surgical sample Tissue Analysis Pipeline 1:45:22: Morgane Bomsel--SARS-CoV-2 persistence & impact on Long COVID megakaryocytes and platelets 2:00:21: Esen Sefik--A humanized mouse model of SARS-COV-2 RNA persistence 2:11:01: Benjamin Readhead--Toward precision Alzheimer’s: a salivary cytomegalovirus biomarker for patient stratification 2:25:33: Ed Breitschwerdt--Developing advanced diagnostics to identify the Babesia parasite 2:38:31: Jesus Estevez--Persistence of viral antigens and immune-endocrine features in Long COVID 2:48:10: David-Izquierdo Garcia--Evaluation of tissue fibrin accumulation in Long COVID via PET imaging & blood analysis 3:00:00: Lael Yonker--Neutrophil – spike protein interactions in pediatric Long COVID 3:12:44: Shannon Stott--Microfluidics capture of SARS-CoV-2 particles in Long COVID blood 3:23:15: Chiara Giannarelli--Deep characterization of SARS-CoV-2 cardiovascular reservoirs. 3:35:35: Michael Peluso--Pivoting LIINC into the study of ME/CFS pathogenesis—CHIIME program 3:46:30: Steve Deeks--VIPER: a Long COVID diagnostic test validation program 3:59:12: David Putrino--Combination antivirals in the treatment of Long COVID 4:10:57: Beverly Peng--Mapping the landscape of endometriosis tissue 4:19:52: William Eimer--Viruses as drivers of Alzheimer’s disease pathology 4:33:01: Tim Henrich--Long COVID tissue biopsy program update 4:44:01: Francis Eun Lee--Use of MENSA to identify SARS-CoV-2 persistence and viral reactivation in Long COVID 4:58:27: Marta Mirabent--SARS-CoV-2 persistence & T cell activity in the female reproductive tract 5:11:08: Mark Painter--T cells as biosensors of viral persistence in Long COVID 5:28:27: Marcelo Freire--Proteomics reveals immune markers in Long COVID vagal nerve stimulation clinical trial 5:40:02: Max Qian--Long COVID endotype identification 5:53:07: Mario Murakami--Vagus nerve sensitivity as a common infection-associated chronic disease mechanism 6:02:40: Zian Tseng--The COVID POST SCD (POstmortem Systematic invesTigation of Sudden Cardiac Death) Study 6:15:31: Michael Peluso--Supporting the immune response in Long COVID: INTERRUPT-LC