DNA methylation biomarker discovery for complex diseases

DNA methylation describes the addition of a methyl group to the DNA molecule, which, in the human genome, most commonly occurs at cytosine nucleotides. These methylated cytosines are often found in concentrated regions known as CpG islands and play a key role in gene expression and function. Whole genome bisulfite sequencing (WGBS) is the gold standard technique for genome-wide CpG analysis; however, it is expensive and provides relatively low depth of coverage. Alternatively, array-based methylation analysis combines sensitivity with lower costs but can only survey a limited number of CpGs (typically up to 850,000), making it unsuitable for biomarker discovery applications. This webinar will detail how the Twist Human Methylome Panel can overcome these challenges, enabling affordable, sensitive, and high-coverage analysis of over four million CpGs across both DNA strands. *Results from customer experiences are not predictive of results in other cases. Results in other cases may vary.