New LONGEVITY Clock that predicts the chronic DISEASES of AGING

The Buck Institute for Research on Aging have introduced the concept of inflammation as the 10th hallmark of aging. Alive by Science 10% Discount Code: MYNMN (https://bit.ly/3euiDd5) DoNotAge.org 10% Discount Code: MYNMN (https://bit.ly/3oaKgLv) I hope you enjoy my content and find it interesting or informative, hopefully both, if so, please consider supporting the channel by signing up to the one you prefer: *Buy me a Kofi: https://ko-fi.com/mynmnexperiment *Patreon: https://bit.ly/3hhfjl5 *Subscribestar: https://bit.ly/3psYo23 https://www.nature.com/articles/s4358... https://www.buckinstitute.org/news/fi... https://www.sciencedaily.com/releases... https://www.worldhealth.net/news/firs... https://worldnewsera.com/news/science... https://phys.org/news/2021-07-immune-... https://www.livescience.com/clock-too... ality.html Researchers from the Buck Institute and Stanford University have created an inflammatory clock of aging named iAge. iAge measures inflammatory load and predicts multi-morbidity, frailty, immune health, and cardiovascular aging. Using ‘Deep Learning’, a form of Artificial Intelligence, in studies of the blood immunome of 1001 people, researchers identified a modifiable chemokine associated with cardiac aging which can be used for early detection of age-related pathology and provides a target for interventions. David Furman, Ph.D and Associate Professor at the Buck Institute and senior author of the study said "Standard immune metrics which can be used to identify individuals most at risk for developing single or even multiple chronic diseases of aging have been sorely lacking. Bringing biology to our completely unbiased approach allowed us to identify a number of metrics, including a small immune protein which is involved in age-related systemic chronic inflammation and cardiac aging. We now have means of detecting dysfunction and a pathway to intervention before full-blown pathology occurs." Nazish Sayed, MD, Ph.D. and Assistant Professor of Vascular Surgery at Stanford Medicine said that the study identified the soluble chemokine CXCL9 as the strongest contributor to iAge and "We showed that CXCL9 upregulates multiple genes implicated in inflammation and is involved in cellular senescence, vascular aging and adverse cardiac remodeling. Silencing CXCL9 reversed loss of function in aging endothelial cells in both humans and mice.” Results from the initial analysis (which included information from 902 individuals) were validated in an independent cohort of centenarians and all-cause mortality in the Framingham Heart Study. Professor Furman says when it comes to health and longevity the ‘age’ of a person’s immune system certainly trumps the chronological information that can be derived from a driver's license. "On average, centenarians have an immune age that is 40 years younger than what is considered 'normal' - and we have one outlier, a super-healthy 105 year-old man (who lives in Italy) who has the immune system of a 25 year old." In a second study, results involving cardiac health were also validated in a separate group of 97 extremely healthy adults (aged between 25 and 90) recruited from Palo Alto in California. Professor Furman said that researchers found a correlation between CXCL9 and results from ‘pulse wave velocity testing’. "These people are all healthy according to all available lab tests and clinical assessments, but by using iAge we were able to predict who is likely to suffer from left ventricular hypertrophy and vascular dysfunction." Professor Furman says the tool can be used to track someone's risk of developing multiple chronic diseases by assessing the cumulative physiological damage to their immune system. For example, age-related frailty can be predicted by comparing biological immune metrics with information about how long it takes someone to stand up from a chair and walk a certain distance as well as their degree of autonomy and independence. DISCLAIMER: This video and description contain discount codes, which means that if you use the code, I will receive a small commission. FAIR-USE COPYRIGHT DISCLAIMER Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. #DavidFurman #hallmarksofaging #longevity