Efectos del depósito de gadolinio en el cerebro sobre la función motora o conductual.

Join me as we review this article, published online today, August 31, in Radiology by a group of radiologists and pharmacologists from the University of Tokyo and Chiba University in Japan. Their aim was to study whether the accumulation of gadolinium in brain structures causes any motor or behavioral changes in well-studied and widely reproducible animal models. The authors attempted to answer this question by examining three cohorts of mice after repeated injections of saline solution as a control, a linear Gadolinium-Based Contrast Agent (GBCA) (gadodiamide, Omniscan), or a macrocyclic GBCA (gadoteridol, ProHance). For 8 weeks, 17 female BALB/c mice received saline solution (control group, group A), a macrocyclic GBCA (group B), or a linear GBCA (group C). Every two weeks, brain MRI scans were performed to monitor the change in signal intensity induced by gadolinium accumulation. After the injection period, locomotor skills, anxiety levels, and memory were assessed using the rolling bar performance test, open field test, positive-elevated maze test, light-dark anxiety test, locomotor activity assessment test, passive avoidance memory test, Y-maze test, and forced swim test. Only animals injected with a linear ACBG showed gadolinium accumulation in the bilateral deep cerebellar nuclei, which was validated by MRI. At 8 weeks, group C had a higher contrast ratio than groups A and B. Behavioral analyses revealed that mice injected with linear or macrocyclic ACBG had similar locomotor skills, anxiety levels, and short- and long-term memory. In conclusion, no motor or behavioral changes were found in mice with gadolinium accumulation in the brain. The findings also show that gadolinium-based macrocyclic contrast agents are safe. Article link: https://pubs.rsna.org/doi/10.1148/rad... Website link: www.memorandum.mx