EXERCISE-INDUCED OXIDATIVE STRESS: HISTORY, CAUSE, AND CONSEQUENCES

ECSS Prague 2019 The 24th Annual Congress of the European College of Sport Science will take place in Prague between 3rd and 6th July 2019. It will host some of the world's leading sports scientist who will continue to share their latest research and findings from across the academic and applied fields. Find out more at the ECSS 2019 website: http://bit.ly/ECSSPrague2019 How to register: http://bit.ly/ECSSreg View the programme at: bit.ly/ECSSprog ************ 23rd annual ECSS Congress Dublin/Ireland, July 4-7 2018 EXERCISE-INDUCED OXIDATIVE STRESS: HISTORY, CAUSE, AND CONSEQUENCES Author: Powers, S. University of Florida The observation that living cells produce free radicals was first reported in 1954 and this important discovery launched the field of free radical biology. The detection that contracting skeletal muscles produce reactive species followed in the 1980’s and many studies have now confirmed that prolonged exercise is associated with an accumulation of oxidation products in the active muscles. This presentation will provide an overview of the history of research in exercise-induced oxidative stress and will highlight the potential causes and consequences of exercise-induced oxidant production. In particular, the sources of radical production in contracting muscles will be debated followed by a discussion of the role that radicals play in the regulation of skeletal muscle force production. Moreover, evidence that reactive species play a key role as signal transduction messengers in exercise-induced muscle adaptation will also be highlighted. Finally, the possibility that exercise-induced production of reactive oxygen species is an important player in epigenetic events in skeletal muscle will be introduced in hopes of stimulating future research.