Bilirubin metabolism ( Heme catabolism) by Dr Rajesh Jambhulkar

Heme catabolism Heme degradation in macrophages Bilirubin transport with albumin Bilirubin metabolism 1. Uptake by hepatocytes by facilitated diffusion 2. Conjugation of unconjugated bilirubin 3. Secretion in to bile canaliculi by active transport through MRP 2 Congenital causes UNCONJUGATED BILIRUBIN INCREASE 1. Crigler Najjar type 1 2. Crigler Najjar type 2 3. Gilbert syndrome Conjugated bilirubin increase 1. Dubin Johnson syndrome 2. Rotor syndrome Books Harper's illustrated Biochemistry 31st