Upgrading the Physiological Relevance of Human Brain Organoids

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Recorded on 06/13/2024. [Show ID: 39456] Donate to UCTV to support informative & inspiring programming: https://www.uctv.tv/donate Please Note: Knowledge about health and medicine is constantly evolving. This information may become out of date. More videos from: Breaking News in Stem Cells: Southern California Stem Cell Seminar Series (https://www.uctv.tv/stem-cell/stem-ce...) More from: Stem Cell Channel (https://www.uctv.tv/stem-cell) Explore More Health & Medicine on UCTV (https://www.uctv.tv/health) UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more. Explore More Science & Technology on UCTV (https://www.uctv.tv/science) Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells. UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv)