Hepatitis C | Clinical Medicine

Premium Member Resources: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy breaks down Hepatitis C with a clear, high-yield approach focused on recognition, diagnosis, and management. This video builds a practical framework for understanding how Hepatitis C is transmitted, why it so often becomes chronic, and how it leads to progressive liver disease over time. We begin with epidemiology and transmission, emphasizing bloodborne spread through injection drug use, needle-stick exposure, and other high-risk blood exposures. Zach then walks through the pathophysiology, highlighting why Hepatitis C commonly persists as a chronic infection and how ongoing inflammation drives fibrosis, cirrhosis, and long-term complications. Next, the lecture covers the clinical presentation and diagnosis, focusing on the often-silent nature of early disease, the laboratory pattern of hepatocellular injury, and the stepwise testing approach using Hepatitis C antibody screening followed by confirmatory RNA testing. The session then focuses on complications and management, including chronic hepatitis, cirrhosis, hepatocellular carcinoma, and extrahepatic manifestations. Zach also reviews modern antiviral therapy, treatment goals, and the importance of screening and follow-up in high-risk patients. Finally, the lecture highlights prevention principles, including harm reduction, screening strategies, and the absence of a vaccine. Enjoy the lecture, and please support us below! Table of Contents: 0:00 Lab 0:28 Etiology of Hepatitis C Virus (HCV) 7:34 Transmission of HCV 9:04 Lifecycle of HCV 22:43 Acute Hepatitis 27:56 Chronic Hepatitis 43:42 Diagnostic Approach to HCV 48:14 Treatment of HCV 53:08 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #infectiousdisease #hepC