lead optimization in drug development

directory of Chem Help ASAP videos: https://www.chemhelpasap.com/youtube/ The goal of lead optimization in drug development is to design a molecule that satisfies the safety criteria for an IND submission with sufficient promise for efficacy. Lead optimization begins with a molecule that was identified during lead discovery. The original lead will have good properties (potency, ADME) that need to be improved for the molecule to enter clinical trials. Lead optimization involves a series of structural changes that allow the optimization team to understand the structure-activity relationships of the lead.