John Prine, Amanda Shires, Jason Isbell, "In Spite of Ourselves"
"In Spite of Ourselves" is the title track, and only Prine-penned song, on John's 13th studio album (1999), an album of duets. This performance at Ryman Auditorium, 11 March 2016, the first of several with surprise guests Shires and Isbell.

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John Prine and Iris DeMent - In Spite of Ourselves (Live From Sessions at West 54th)

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John Prine & Kacey Musgraves - In Spite of Ourselves

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Jason Isbell & The 400 Unit - Dress Blues

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Working for John Prine

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The Drop: Amanda Shires

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Amanda Shires & John Prine - In Spite of Ourselves / Unwed Fathers (Live)

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Jason Isbell Responds to Rumors He Had an Affair

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Ryan Adams: "Sweet Carolina" (w/Jason Isbell), Outside Lands 2016

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John Prine, Jason Isbell, Amanda Shires, "Storm Windows"

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Jason Isbell & Amanda Shires Perform “Cover Me Up” at Country Music Hall of Fame

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John Prine & Sturgill Simpson Live At GRAMMY Pro Up Close & Personal

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Amanda Shires - Empty Cups (Feat. Maren Morris) (Official Live Session)

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Brandi Carlile Pays Tribute To John Prine: "Hello In There"

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Jason Isbell f/Brandi Carlile - Clocks & Spoons (John Prine cover) - 7/21/18 - Thompson's Point

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John Prine and Steve Goodman's Chicago Years -Bonnie Koloc

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Kacey Musgraves sings "Burn One With John Prine" to John Prine

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Jason Isbell & Amanda Shires - I Won't Back Down (Live @ PettyFest Austin)

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Jason Isbell: Tiny Desk Concert

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John Prine - "Speed of the Sound of Loneliness" (Live)
![Jason Isbell Full Performance + Interview [LIVE Music Lounge] | Austin City Limits Radio](https://i.ytimg.com/vi/c-b7zoscolE/hqdefault.jpg?sqp=-oaymwEjCNACELwBSFryq4qpAxUIARUAAAAAGAElAADIQj0AgKJDeAE=&rs=AOn4CLALn7yTGVQWuSCzFDs0kPywbhFd4A)
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