Osteogenesis Imperfecta (OI) - Brittle Bone Disease - Causes, Symptoms, Diagnosis, Treatment

Osteogenesis Imperfecta (OI) is an autosomal dominant (or autosomal recessive) genetic disease affecting COL1A1 and COL1A2 genes, characterized by defective synthesis of type I collagen leading to brittle bones, brittle, opalescent teeth, increased fractures even after minimal trauma, short stature, decreased growth velocity, scoliosis, hearing loss (abnormal ear ossicles— malleus, incus, stapes), bone deformities, blue sclera, conductive deafness, triangular face, tendon instability, hypermetabolism, hypoplasia of chest cavity, intrauterine fetal demise (IUFD). Can be complicated by osteoporosis. Treatment includes bisphosphonates and surgery. Biochemistry and Genetics videos for doctors, nurses, physician assistants, dentists, veterinarians. 💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.c... 💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.c... 🤰 ObGyn Highyields Course: https://www.medicosisperfectionalis.com/ 🚨 Emergency Medicine HighYields Course: https://www.medicosisperfectionalis.com/ 😷 Surgery HighYields Course: https://www.medicosisperfectionalis.com/ 💊 📛 Toxicology Course: https://www.medicosisperfectionalis.com/ ❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/ 🧪Acid-Base Course: https://www.medicosisperfectionalis.c... 🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/ 🧪 Electrolytes Course: https://www.medicosisperfectionalis.com/ 🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.c... 🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/ 💊 General Pharmacology (Pharmacokinetics & Pharmacodynamics): https://www.medicosisperfectionalis.com/ 📝 Download my handwritten notes: www.medicosisperfectionalis.com/ ⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/ 🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG 🎁Free Stuff: https://www.medicosisperfectionalis.com/ 💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/ YouTube PLAYLISTS: ► 🧠 Physiology Playlist:    • Physiology Introduction - What is Physiolo...   🧫 🦠 Microbiology and Infectious Diseases Playlist:    • Microbiology & Infectious Diseases   ► 🩸 Hematology videos:    • Hematology   ► 💪 Rheumatology:    • Rheumatology   ► ❤️ Cardiac Pharmacology:    • Cardiac Pharmacology   ► Biochemistry 🧪 :    • Biochemistry -  MCAT, DAT, PCAT, NEET, Pre...   ► 🙌 Support me on cash app: https://cash.app/$medicosis/ ► Support me on Stripe: https://donate.stripe.com/3cs02Hb9ca2... ► 😍 Support me on Patreon:   / medicosis   ► Support me on Venmo: Venmo: https://venmo.com/medicosis ► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/ ► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/ ► 😚 Join my Channel on YouTube:    / @medicosisperfectionalis   --If you’ve joined my channel on youtube (the join button that's next to the subscribe button), go to the "membership tab" and you will find some member-only posts/videos. ► 👨‍🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/ 📚 Recommended Books: https://www.amazon.com/shop/medicosis... ► ❓If you have any questions, please email me at: [email protected] 🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/ ►Website: https://www.medicosisperfectionalis.com/ ►Patreon:   / medicosis   ►YouTube:    / medicosisperfectionalis   or: ► Like my page on Facebook   / medicosis   ►Follow us on Instagram here:   / medicosisperfectionalis   ►PayPal: https://www.paypal.me/perfectionalis/ ►Venmo: @medicosis ►Facebook:   / medicosis   ►Twitter:   / medicosis   ►SoundCloud:   / medicosis   ►TikTok: www.tiktok.com/@medicosisp/ ►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197/ ►Snapchat:   / medicosis   ►Pinterest:   / medicosisperfectionalis   ►Rumble: https://rumble.com/user/MedicosisPerf... ► Tumblr:   / medicosis   Thank you for supporting my channel! Love ❤️& Happy studying!! 😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/me... 📱Save on your phone bill: http://fbuy.me/q6bMj 📊 My favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ ☁️ Get 20 GB of online storage for FREE: https://mega.io/?aff=ZSJvkba-Ov0 🙋‍♀️ Qbank (TrueLearn): https://truelearn.referralrock.com/l/... 🙌 Support the channel: https://donate.stripe.com/3cs02Hb9ca2...