Tubuloglomerular feedback

In order to maintain proper nephron function, the production of glomerular filtrate and subsequent nephron flow rates must be regulated. Flow that is too fast or too slow will dramatically alter nephron transport as those mechanisms are not ubiquitously regulated based upon the movement of solutes along the nephron. In other words, fast flow will reduce time available for nephron transport, reducing reabsorption and enhancing excretion, while slow flow results in elevated reabsorption and reduced excretion. For this reason, it is adaptive that nephron flow and content at the distal tubule is fed back to the glomerulus to aid in the regulation of GFR, matching the production of filtrate with the transport abilities of the nephron.