BREAKTHROUGH Skin Age Reversal: New Enzyme Removed 40 Years Of Damage

Scientists just reversed a type of aging damage that was called permanent for 40 years. Revel Pharmaceuticals used an AI-designed enzyme called CMLase to strip decades of glycation and AGEs out of human tissue, taking 75-year-old skin below the level of 31-year-old skin on a key aging marker. Aging reversal, in real human tissue, this month. And it landed days after Matt Kaeberlein, one of the most respected longevity scientists alive, called reversing biological aging a "myth." So we put the myth next to the paper. This is the enzyme, the AI, and the anti-aging breakthrough longevity Twitter cannot stop posting about, with David Sinclair, Bryan Johnson, Aubrey de Grey, and the All-In podcast all weighing in. We break down what glycation and AGEs actually do to your skin, arteries, and eyes, how the enzyme was discovered with AlphaFold and directed evolution, whether a real anti-aging skin cream is coming, and how close we actually are to reversing human aging. Real age reversal is no longer just a headline. LONGEVITY LATTE PRE-ORDER: [INSERT LINK] TIMESTAMPS 0:00 - Cold Open 2:16 - Intro 2:38 - Sponsor: Longevity Latte 3:55 - What the Damage Actually Is 4:50 - "All In" Explanation 5:36 - The Results 6:29 - What It Could Fix 9:47 - They Used an AI to Build It 13:10 - Enzymes For Everything? 14:05- Looking Past the Hype 16:50 - Conclusion SOURCES & LINKS Nature Communications paper (Reversal of protein chemical aging by enzymatic deglycation): https://www.nature.com/articles/s4146... Revel Pharmaceuticals news: https://revelpharmaceuticals.com/news Revel Pharmaceuticals (disease targets): https://revelpharmaceuticals.com Aubrey de Grey post: https://x.com/aubreydegrey/status/207... David Sinclair post: https://x.com/davidasinclair/status/2... Bryan Johnson post: https://x.com/bryan_johnson/status/20... Avi Roy post: https://x.com/agingroy/status/2077345... Dr. Afshine Emrani post: https://x.com/afshineemrani/status/20... Dr. David Barzilai post (paper quote): https://x.com/agingdoc1/status/207746... AI in biotech thread: https://x.com/m_goes_distance/status/... Weco AI recursive self-improvement (AIDE2): https://www.weco.ai/blog/first-eviden... Kaeberlein roundtable:    • LONGEVITY EXPERTS: How Close Are We to Sol...   Our cartilage / 15-PGDH episode:    • Arthritis Cure BREAKTHROUGH: Regrow Young ...   All-In Podcast Science Corner (David Friedberg):    • Can the AI Industry Regulate Itself? Strip...   FDA, Is It a Cosmetic, a Drug, or Both?: https://www.fda.gov/cosmetics/cosmeti... 500 Dalton rule (Bos and Meinardi, Experimental Dermatology): https://pubmed.ncbi.nlm.nih.gov/10839... TOPICS COVERED glycation, deglycation, AGEs, carboxymethyl-lysine, CML, CMLase, Revel Pharmaceuticals, Aaron Cravens, Calico, SENS, Aubrey de Grey, David Sinclair, Bryan Johnson, Avi Roy, Matt Kaeberlein, AlphaFold, directed evolution, enzyme engineering, protein aging, collagen, arterial stiffness, skin aging, eye lens, glucosepane, recursive self-improvement, AIDE2, 15-PGDH, cartilage regeneration, longevity biotech, David Friedberg, All-In Podcast, anti-aging cream, healthspan, lifespan LATEST EXCLUSIVE INTERVIEW:    • Watch Your Brain Get Sharper | Muse Founde...   Disclaimer: This video is educational and informational only and does not constitute medical advice. Consult a qualified clinician before making health or treatment decisions. EXCLUSIVE INTERVIEWS & BONUS CONTENT Patreon: https://patreon.com/u29506604?utm_med... YT Membership:    / @longevitysciencenews   PRODUCTION CREDITS Executive Producer, Keith Comito ‪@Retromancers‬ Host, Producer, Writer, Emmett Short ‪@emmettshort‬