Solvent Selection in Pharmaceutical Crystallization Process Development

Choosing an appropriate solvent is the cornerstone of good crystallization development. The solvent system from which an active pharmaceutical ingredient (API) is crystallized, influences solubility, growth and nucleation kinetics, impurity purging, polymorph control, solvation propensity and crystal morphology. In this webinar, Dr Marko Ukrainczyk, senior scientist at APC, will demonstrate the early phase crystallization process development strategy, through case studies of propriety API molecules, chosen as examples of the cooling and antisolvent crystallization workflows. The use of Raman spectroscopy will also be demonstrated in the context of early form/solvates and impurity identification.