DNA Repair II: Nucleotide Excision Repair (NER) & Mismatch Repair (MMR) | Molecular Biology Series

We will learn about nucleotide excision repair and mismatch repair mechanism in this series - complete molecular biology for CSIR NET JRF June/Dec 2026 and GATE 2026 exams by Expert IFAS faculties. Protecting the genome is a full-time job for the cell! In this video, we explore the high-fidelity systems of NER and MMR, explaining their pathways, key enzymes, and what happens when these systems fail. 🔥 Join India's Best Life Science Coaching - IFAS Online! 🔥 Super Emotion Batch 7.0 Live Online Batch: Starts on 12th Jan 2026 🔥 Offline Batches at Jodhpur/Pune: Starts on 11th Jan 2026 🎯 Why IFAS is India's No. 1 Choice? (Our Results Speak): We have consistently produced Top Rankers in CSIR NET Life Sciences. 🏆 CSIR NET June 2025: 4500+ Selections (AIR 1, 2, 6, ...) 🏆 CSIR NET Dec 2024: 3000+ Selections (AIR 5, 6, 7, 8...) 🏆 CSIR NET June 2024: 2000+ Selections (AIR 3, 10, 13...) 🏆 CSIR NET Dec 2023: 1200+ Selections (AIR 2, 4, 5...) 📄 View Detailed Result Sheet: 📌 https://drive.google.com/file/d/1THh6... 🎯 Target Audience: This video is highly beneficial for students preparing for: 🚀 CSIR NET Life Science (June 2026) 🚀 GATE Biotechnology (BT) & Life Sciences (XL) 🚀 DBT JRF 🚀 MH SET, WB SET, K SET, & other State Eligibility Tests 🚀 M.Sc. & Ph.D. Entrance Exams 🔗 Important Links: 🌍 Visit our Website: https://ifasonline.com/csir-net/life-... 📞 Contact for Queries: 9172266888 📲 WhatsApp: https://api.whatsapp.com/send?phone=9... 🔥 Qualification Prediction (Free Tool): https://ifasonline.com/QualificationP... 📘 Get Detailed Free Counseling: https://ifasonline.com/csir-net/life-... 📲 Download IFAS App: 📌 Android: https://play.google.com/store/apps/de... 📌 Ios: https://apps.apple.com/us/app/ifas/id... 📘 Buy CSIR NET Life Science Books: https://ifasonline.com/csir-net/life-... 🔥 Our Social Media Platforms: 📌 Telegram: https://t.me/NET_GATE_SET_LifeScience... 📌 Instagram:   / csir_net_life_science_ifas   📌 Facebook:   / ifasls   📌 WhatsApp: https://api.whatsapp.com/send?phone=9... 💡 Stay Updated, Stay Ahead! 🔹What You Will Learn: 1. Nucleotide Excision Repair (NER) The "Bulky" Fixer: How NER identifies DNA distortions like pyrimidine dimers caused by UV light. Prokaryotic NER (UvrABC System): The roles of UvrA, UvrB, UvrC, and UvrD. Eukaryotic NER: Global Genome Repair (GGR) vs. Transcription-Coupled Repair (TCR). Clinical Significance: The link between NER defects and Xeroderma Pigmentosum. 2. Mismatch Repair (MMR) Correcting Replication Errors: How the cell identifies the "wrong" base after DNA synthesis. Prokaryotic MMR (MutHLS System): How E. coli uses DNA methylation to distinguish the parent strand from the new daughter strand. Eukaryotic MMR: The homologs (MSH and MLH proteins) and how they function without hemimethylation. Clinical Significance: MMR mutations and their role in HNPCC (Lynch Syndrome). 💡 Why watch? This video uses clear diagrams and step-by-step enzymatic walkthroughs to make complex molecular pathways easy to visualize. Perfect for exam prep (CSIR-NET, GATE, NEET-PG, or university finals). This video has following search items #csirnet2026 #IFAS #CSIRNETLifeScience #GATE2026 #KCSir #LifeScience #BiologyLecture #csirnet #csirnetlifescience #csirjrf #csirnetpreparation #csirugcnet #csirnetlifesciences #setlifescience #gatelifescience #gatebt #gatexl #complete #bestcoaching