05- Pharmacology 4: Antimetabolic Antibiotics: Sulfonamides, Trimethoprim, and Fluoroquinolones

رابط ملف الشرح https://t.me/alfakihdheya/278 شرح شامل ومبسط لمجموعات الأدوية التي تعطل العمليات الحيوية للبكتيريا، وتشمل: السلفوناميدات (Sulfonamides): آلية تثبيط تصنيع حمض الفوليك (Folate) من مادة PABA. تريميثوبريم (Trimethoprim): تثبيت إنزيم Dihydrofolate reductase واستخدامه في علاج عدوى البروستاتا والمسالك البولية. كوتريموكسازول (Cotrimoxazole): المزيج القاتل للبكتيريا (Bactericidal) المكون من Sulfamethoxazole و Trimethoprim. الفلوروكينولونات (Fluoroquinolones): أجيالها المختلفة وآلية عملها في تثبيط إنزيمات DNA gyrase و Topoisomerase IV لمنع تكاثر الحمض النووي. الآثار الجانبية والتحذيرات: شرح لآثار مثل Crystalluria، واليرقان النووي، والتحذيرات الحديثة من الـ FDA بشأن التهاب الأوتار والاعتلال العصبي.

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