SABCS 2025 Recap: Breast Cancer Updates for 2026

A breakthrough in breast cancer treatment is here. In this recap of the San Antonio Breast Cancer Symposium (SABCS) held in December 2025, Dr. Francisco Esteva and patient advocate Victoria Goldberg discuss the major breast cancer updates for 2026, including the practice-changing results from the DESTINY-Breast09 trial, HER2CLIMB-05, lidERA trial, and more. We break down the unprecedented 40-month progression-free survival data for HER2+ metastatic breast cancer, the new role of T-DXd (Enhertu), and emerging options for Triple Negative and HR+ disease. This episode offers a unique perspective on clinical trials by combining expert oncology analysis with the survivor voice. #SABCS2025 #BreastCancer #MetastaticBreastCancer #Oncology #clinicaltrials CHAPTERS 00:00 The 40-Month Breakthrough 01:10 Meet Dr. Francisco Esteva 05:00 SABCS 2025 General Overview 09:20 PI3K Mutations in HER2+ 12:40 DESTINY-Breast09 Results 17:30 Cleopatra vs. T-DXd 20:30 HER2CLIMB-05 & Tucatinib 24:00 Brain MRI Screening Debate 28:45 SERDs & Liquid Biopsies 34:00 Triple Negative Updates 38:15 HER2-Low & Ultra-Low About Dr. Esteva Francisco J. Esteva, MD, PhD, is a board-certified medical oncologist based in New York City, specializing in breast cancer research and treatment. He currently serves as Chief of the Division of Hematology and Medical Oncology at Lenox Hill Hospital and has led over 100 clinical trials focused on next-generation cancer diagnostics and therapies. Dr. Esteva has held academic leadership positions at MD Anderson Cancer Center and New York University. He is a recipient of the Susan G. Komen Physician of Impact Award and serves on the American Cancer Society Board of Advisors. He is dedicated to helping patients navigate the latest advances in precision medicine. Subscribe to stay updated on the latest breakthroughs in breast cancer care. Disclaimer This video is for educational purposes only and does not constitute medical advice. Always consult with your personal oncologist or healthcare team regarding your specific diagnosis and treatment plan. The views shared in this video represent Dr. Esteva’s personal opinions and do not reflect those of his employer. This video is not sponsored. Any mention of products, medications, or brands is for educational purposes only and does not imply endorsement. Advertisements that may appear are placed by YouTube; I am not affiliated with, nor do I endorse, any advertised products or services.