Food Noise Explained: GLP-1s Change Everything! Talking with Dr. Michelle Cardel

Laraine Durham of The Downsized sits down with leading obesity scientist and registered dietitian Michelle Cardel for an insightful and deeply personal conversation about GLP-1 medications, nutrition, and what it really takes to succeed long term. In this episode, Laraine explores what viewers need to understand about GLP-1s including Zepbound, Mounjaro, Wegovy, Ozempic, tirzepatide, semaglutide, and the newer oral option orforglipron (Foundayo). Drawing from more than 20 years of obesity research, Dr. Cardel explains how these medications work beyond appetite suppression and why they are changing the way we treat the disease of obesity. Laraine also shares her own real-world experience, having lost more than 50 pounds on tirzepatide, and brings a patient-first perspective to topics like food noise, nutrition, and sustainable lifestyle changes. Together, they break down the science into practical, actionable insights viewers can actually use. This conversation covers: • Why eating enough on GLP-1s is critical for health • Protein targets and how to realistically hit them • The 30-30-30 framework for long-term success • Why resistance training matters for preserving muscle • How GLP-1s are impacting food noise, alcohol use, and eating behaviors • What viewers should know before starting a GLP-1 Dr. Cardel also discusses her new role at Kailera Therapeutics and what’s coming next in obesity treatment. Learn more about Kailera Therapeutics here: 👉 https://kaileratherapeutics.com Whether you are currently using a GLP-1, considering starting, or trying to better understand the science, this episode delivers a clear, credible, and patient-centered perspective. +++++++++++++++++++++++++++++++++++++++ Get your Hume BodyPod today and use our exclusive Downsized code for up to 20% total savings! 👉 Use our Code: THEDOWNSIZED Link to purchase: https://humehealth.com//discount/THED... Start your weight loss journey today! We use Mochi Health: https://app.joinmochi.com/eligibility... Use Laraine’s code for $40 off: QIYGO8. Me Again Iphone GLP-1 App: https://apps.apple.com/us/app/meagain... SHOP OUR AMAZON STORE: https://a.co/d/0gGe1MYq BOOK THE DOWNSIZED AT SEA CRUISE 2026: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED:    / @thedownsized   FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ +++++++++++++++++++++++++++++++++++++++ 00:00 Welcome to Downsized 01:05 Meet Dr Cardell 03:11 Why Obesity Research 05:43 Obesity as Disease 06:35 GLP1 Plus Lifestyle 08:00 Eating Enough on GLP1 10:48 Protein Targets Explained 12:41 Shakes Bars and Budget 13:55 Maintenance and 303030 17:21 Resistance Training Matters 19:51 Food Noise Questionnaire 20:10 Measuring Food Noise 21:53 Building the Questionnaire 24:27 Clinic Ready Five Questions 26:22 New Role in Obesity Care 26:51 Who Qualifies for GLP-1s 28:16 Beyond Weight Alcohol Effects 30:34 Binge Eating Improvements 33:30 Biology Versus Willpower 36:08 Simple Versus Easy 38:16 Nonresponders and Pipeline 39:11 Closing Kindness and Stigma