51. Methylation Optimisation: What The Biohacking Trend Gets Wrong

Methylation has become one of the biggest trends in biohacking, functional medicine, and wellness circles. From MTHFR gene testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if the story is more complicated? In this episode of The Histamine Well Podcast, Joanne explores the science behind methylation and explains why more methylation is not always better. Joanne discusses the roles of MTHFR, COMT, folate, vitamin B12, and other key nutrients involved in methylation, while highlighting the often-overlooked issue of overmethylation. You'll learn why genetic reports alone may not provide the full picture, the symptoms associated with excess methyl groups, and the potential risks of taking methylated supplements without proper assessment. Whether you're a practitioner, student, biohacker, or someone navigating histamine intolerance, hormone imbalances, anxiety, or chronic health issues, this episode offers a balanced and clinically informed perspective on methylation optimisation. In this episode, you'll learn: • What methylation is and why it matters • How methylation influences genes, hormones, detoxification, and neurotransmitters • The difference between undermethylation and overmethylation • The role of MTHFR and COMT gene variants • Signs and symptoms of excess methyl groups • Why methylated supplements can worsen symptoms for some people • The limitations of relying solely on genetic testing • A more personalised approach to supporting methylation 👉 Learn more or book a consultation: https://joannekennedynaturopathy.com 👉 The Ultimate Bundle for Managing Histamine Intolerance: https://joannekennedynaturopathy.com/... 👉 At Home Saliva Methylation Test (10% off – HISTAMINEWELL10): https://joannekennedynaturopathy.com/... 👉 Histamine & Methylation Online Group Coaching Course for Practitioners & Students Application: https://joanne-kennedy.mykajabi.com/h... 👉 Book a 1:1 consult: https://joannekennedynaturopathy.com/... 👉 Suggest a podcast topic: https://joannekennedynaturopathy.com/... 👉 Histamine Well Podcast (Apple): https://podcasts.apple.com/us/podcast... 👉 Histamine Well Podcast (Spotify): https://open.spotify.com/show/4kroSB6... 👉 Instagram:   / joannekennedynaturopath   TIME STAMPS: 00:00 Methylation Hype Check 01:05 Podcast Intro 02:41 What Methylation Does 04:13 Why Gene Reports Mislead 05:24 COMT and Overmethylation 06:20 Supplement Side Effects 07:46 Training for Practitioners 09:01 Mood Sense Testing 09:25 Treat the Bigger Picture 11:14 Wrap Up and Next Steps #methylation #mthfr #Biohacking #functionalmedicine #histamineintolerance #hormonehealth