GENÉTICA E A COLUNA: O QUE OS ESTUDOS REVELAM SOBRE A ESCOLIOSE

In this video, you will understand why scoliosis—both congenital and adolescent idiopathic scoliosis—has deep genetic roots, and why this information is fundamental for early diagnosis, family counseling, and the development of future treatments. We explain the differences between congenital scoliosis, caused by failures in the embryonic signaling pathways that form the vertebrae, and adolescent idiopathic scoliosis, the most common pediatric spinal deformity, affecting 2 to 3% of children and having a familial origin in up to 97% of cases. You will understand which genomic loci have already been replicated in multiple populations—including the LBX1 and GPR126 genes—why variable penetrance means that carriers of the same gene can have completely different curves, and why girls are much more affected than boys even when sharing the same risk genes. We also discuss embryonic signaling pathways — Notch, Wnt, and FGF — which, when altered, result in segmentation and vertebral formation failures causing congenital scoliosis, and how environmental factors such as gestational hypoxia can interact with genetic predisposition to generate malformations even without a known mutation. Accessible content for both healthcare professionals and families living with scoliosis. Subscribe to the channel, activate the bell, and leave your question or the topic you want to see in future videos in the comments! #AllAboutSpine #ScoliosisCauses #AdolescentIdiopathicScoliosis #SpineGenetics #CongenitalScoliosis Is adolescent idiopathic scoliosis hereditary? Why does scoliosis affect more girls than boys? What is the difference between congenital and idiopathic scoliosis? What causes congenital scoliosis? Which genes are associated with idiopathic scoliosis? What is the LBX1 gene in scoliosis? What is GPR126 and its relationship to scoliosis? Why are relatives of patients with scoliosis at higher risk? What is genetic penetrance in scoliosis? Why can carriers of the same gene have different curves? How to identify genetic predisposition to scoliosis? What are genome-wide association studies in scoliosis? Is there a genetic test for idiopathic scoliosis? Is a daughter of a mother with scoliosis at higher risk? Why do 97% of scoliosis cases have a familial origin? What are the Notch and Wnt signaling pathways in the spine? How do embryonic defects cause congenital scoliosis? What is a hemivertebra and how does it cause scoliosis? Can hypoxia during pregnancy cause scoliosis in the baby? What is the relationship between melatonin and idiopathic scoliosis? Does estrogen influence the progression of scoliosis? What is early-onset scoliosis? Is infantile idiopathic scoliosis different from adolescent idiopathic scoliosis? How does genetics explain the variability of scoliosis within the same family? Is there a genetic treatment for congenital scoliosis? What is the future of genetic research in scoliosis? What is the TBX6 gene in congenital scoliosis? Why is idiopathic scoliosis more severe in girls? What is the chance that children of patients with scoliosis will develop the disease? How does the environment interact with genetics in scoliosis?