Microbial fermentations simulation models

This tutorial presents the methodology for constructing knowledge-driven simulation models of fermentation processes. You will learn how to integrate the kinetic laws governing microbial reactions, the thermodynamic and kinetic principles of oxygen transfer, and the mass balance equations for key fermentation components to predict the time-dependent variations of substrates, microbial biomass, and metabolites throughout a fermentation. The tutorial focuses on a physiological state model, in which microbial cells transition sequentially from latent to growing and finally to metabolite-producing states.