Perfusion bioreactors

Perfusion is a continuous culturing method in which cells are either retained in the bioreactor or fed back into it using a cell retention device. The harvested medium thus contains no cells, resulting in higher cell concentrations and product yields in the reactor while still reducing the working volume. This technique is increasing in popularity with a general shift of bioreactors towards smaller continuous reactors. In this video, I will discuss opportunities for this method but also drawbacks of this emerging technology. For more videos on this topic, check out our Bioreactors playlist or the playlist Topical research.