Zero Order - Grapefruit Gangster

Grapefruit sounds innocent. In pharmacology, it can be a gangster. This song explains how grapefruit can block CYP3A4 in the gut and make levels of certain medicines climb higher than expected. Full song available on Spotify, Apple Music, YouTube Music and all major streaming platforms — plus more pharmacology bangers from Zero Order. Lyrics: Grapefruit Gangster (gangster!) Sweet but I'm sly (so sly) I block CYP3A4 And I watch your levels climb high Grapefruit Gangster (gangster!) Rude in the gut (uh) One little sip and your safe little dose gets cut Yeah, I roll up at breakfast — pink and sweet Statin think it's stable? Nah, it's about to meet The gut-wall boss, I'm running that gate CYP3A4 — I shut it, too late Simvastatin thought its dose was clean LDL falling like a tidy machine First-pass used to trim it down to size Not on my watch, baby, watch it rise Grapefruit Gangster (gangster!) Sweet but I'm sly (so sly) I block CYP3A4 And I watch your levels climb high Grapefruit Gangster (gangster!) Rude in the gut (uh) One little sip and your safe little dose gets cut I don't drop cholesterol — that ain't my lane I don't touch the name, I just run up the gain Block the breakdown in the gut-wall skin More simvastatin than was supposed to get in And I don't just pause it — nah, I wreck it for good Furanocoumarins, understood? Enzyme's gone, gotta build it brand new So I'm running your blood for a day or two Grapefruit Gangster (gangster!) Sweet but I'm sly (so sly) I block CYP3A4 and I watch your levels climb high Grapefruit Gangster (gangster!) Rude in the gut (uh) One little sip and your safe little dose gets cut Levels climbing and the muscles start to ache Weakness creeping, more than a body can take Rhabdo knocking — yeah, that's on me That's why they keep the statin grapefruit-free I'm sweet in the glass but I'm rude in the gut Sip me with your meds and your dose won't shut — So read the label, check the chart, Or I'm the gangster that tears your dose apart Grapefruit Gangster (gangster!) Sweet but sly CYP3A4 — watch your levels climb high One little sip... and I'm all over you