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Mounjaro injections (whose active ingredient is tirzepatide) cause significant weight loss and help control blood sugar levels. They work by mimicking intestinal hormones (GLP-1 and GIP) that reduce appetite, slow digestion, and increase satiety. Common side effects: When starting treatment, it is normal to experience temporary digestive problems: Nausea and vomiting, diarrhea or constipation, abdominal pain or bloating, and decreased appetite.