Polyarteritis Nodosa Clinical Features | Complications | Management

#drnajeeb #medicines #medicaleducation #pharmacology #polyartists #polyarteritisnodosa Polyarteritis Nodosa | Clinical Features | Complications | Management Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/... --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:10 - Intro 05:00 - Definition 08:00 - Example 10:00 - Complete Polyarteritis nodosa Periarteritis nodosa; PAN; Systemic necrotizing vasculitis Polyarteritis nodosa is a serious inflammatory blood vessel disease. The small and medium-sized arteries become swollen and damaged. Causes Arteries are the blood vessels that carry oxygen-rich blood to organs and tissues. The cause of polyarteritis nodosa is unknown. The condition occurs when certain immune cells attack the affected arteries. The tissues that are fed by the affected arteries do not get the oxygen and nourishment they need. Damage occurs as a result. More adults than children get this disease. People with active hepatitis B or hepatitis C may develop this disease. Symptoms Symptoms are caused by damage to affected organs. The skin, joints, muscle, gastrointestinal tract, heart, kidneys, and nervous system are often affected. Symptoms include: Abdominal pain Decreased appetite Fatigue Fever Joint aches Muscle aches Unintentional weight loss Weakness If nerves are affected, you may have numbness, pain, burning, and weakness. Damage to the nervous system may cause strokes or seizures. Exams and Tests No specific lab tests are available to diagnose polyarteritis nodosa. There are a number of disorders that have features similar to polyarteritis nodosa. These are known as "mimics." You will have a complete physical exam. Lab tests that can help make the diagnosis and rule out mimics include: Complete blood count (CBC) with differential, creatinine, tests for hepatitis B and C, and urinalysis Erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) Serum protein electrophoresis, cryoglobulins Serum complement levels Arteriogram Tissue biopsy Other blood tests will be done to rule out similar conditions, such as systemic lupus erythematosus (ANA) or granulomatosis with polyangiitis (ANCA) Test for HIV Test for hepatitis B and hepatitis C Cryoglobulins Anti-phospholipid antibodies Blood cultures Treatment Treatment involves medicines to suppress inflammation and the immune system. These may include steroids, such as prednisone. Similar medicines, such as azathioprine, methotrexate or mycophenolate that allow for reducing the dose of steroids are often used as well. Cyclophosphamide is used in severe cases. For polyarteritis nodosa related to hepatitis, treatment may involve plasmapheresis and antiviral medicines. Outlook (Prognosis) Current treatments with steroids and other drugs that suppress the immune system (such as azathioprine or cyclophosphamide) can improve symptoms and the chance of long-term survival. The most serious complications most often involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor. Possible Complications Complications may include: Heart attack Intestinal necrosis and perforation Kidney failure Stroke When to Contact a Medical Professional Contact your health care provider if you develop symptoms of this disorder. Early diagnosis and treatment may improve the chance of a good outcome. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures