Reboot Your Nervous System: Procaine IV Therapy for Pain, Stress, and Inflammation

Procaine IV therapy is emerging as a powerful tool for nervous system regulation, pain relief, and inflammation control—far beyond its reputation as a dental anesthetic. In this episode, Dr. Greg Jones sits down with Lexi Yoo, FNP-BC/CPNP, IFMCP, founder of Yoo Direct Health, to explain how Procaine IV therapy can act like a “circuit breaker reset” for a dysregulated autonomic nervous system. You’ll learn mechanisms (membrane stabilization, sodium channel modulation, cytokine balance), the role of metabolites (PABA and DEAE), and why clinicians are pairing procaine with modalities like EMDR, ozone/EBOO, peptides, and prolozone for synergistic outcomes. We cover who benefits most—chronic stress and burnout, anxiety and mood concerns, chronic pain and neuroinflammation, autoimmune and inflammatory conditions—and how to implement Procaine IV therapy safely in modern practice. Lexi shares loading/maintenance protocols, session expectations, and outcome tracking (subjective changes, Oura, HRV, hs-CRP), plus red flags and contraindications. For providers, you’ll hear practical pearls on dosing, bicarbonate buffering, and monitoring; for patients, you’ll gain a clear framework to discuss options with your clinician. If you’re exploring nervous system repair, trauma-informed care, or novel approaches to pain and inflammation, this conversation delivers an evidence-informed, clinically grounded overview you can use today. 📌 About Lexi Yoo, FNP-BC/CPNP, IFMCP Yoo Direct Health | Founder, national speaker, and educator in functional medicine, hormone optimization, and regenerative therapies. Learn more / Training Academy: https://ydhacademy.com/ Instagram: @lexiyooNP 📌 Connect with Dr. Greg Jones IG: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 🔗 Want to learn more? Check out these resources: IFM – Functional Medicine Overview: https://www.ifm.org/ HHS Office on Women’s Health – Stress & Health: https://www.womenshealth.gov/ NIH MedlinePlus – Chronic Pain: https://medlineplus.gov/chronicpain.html 📣 Subscribe + Follow YouTube:    / @drgregjonesnmd   Spotify: https://open.spotify.com/show/2QrMGwC... 🔬 Timestamps 00:00 – Procaine for pain, inflammation & nervous system repair 00:58 – Meet Lexi Yoo, NP (Yoo Direct Health) 03:20 – Procaine 101: Autonomic nervous system “reset” 06:05 – The “circuit breaker” analogy for regulation 07:16 – Mechanisms: metabolites (PABA, DEAE) explained 09:59 – Membrane stabilization & lowering sympathetic tone 11:09 – Who looks dysregulated? Patient profiles 14:23 – Procaine vs ketamine; pairing with EMDR 17:51 – Ideal candidates & top use cases 19:54 – Contraindications + “lightning response” release 22:43 – Interference fields (scars, surgeries, trauma) 24:29 – Dosing & protocols: loading → maintenance 28:45 – What to expect during an IV session 30:05 – Tracking outcomes: subjective + Oura/HRV + labs 33:16 – Synergies: ozone/EBOO, peptides, prolozone 36:35 – Aesthetic/regenerative uses (hair & skin) 37:37 – Training & where clinicians can learn more 39:33 – Where to find Lexi Yoo 40:11 – Dr. Jones’ Oura data: real-world impact #ProcaineIV #NervousSystem #ChronicPain #Inflammation #FunctionalMedicine #TraumaInformedCare Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.