Nonpharmacological Augmentation of Ketamine, Neuroplasticity, and Behavioral Therapy

Morgan Hardy, MD, and William Li, MD, presented a review of evidence on the combinatorial use of cognitive behavioral therapy with ketamine to extend the durability of antidepressant response. Hardy and Li identified the central limitation of ketamine as the brevity of its therapeutic effect—typically waning after approximately 7 days despite rapid onset. They described the metaplastic window induced by ketamine within 12 to 72 hours of infusion as a neurobiological opportunity: preclinical and clinical studies, including their own group's work at Yale and the ENDURE trial targeting patients with major depression and active suicidal ideation, have demonstrated that behavioral therapies delivered within this window produce greater and more durable antidepressant effects than ketamine alone. ---------- 🔗 Read more: https://www.psychiatrictimes.com 📩 Subscribe for more: @PsychTimes 🌐 Visit us: https://www.psychiatrictimes.com ---------- Psychiatric Times is the No. 1 psychiatric publication in the US. Visit us at psychiatrictimes.com for the latest clinical news, expert perspectives, and CME opportunities. #psychiatry #psychiatrictimes #ketaminetherapy #mooddisorders #cognitivebehavioraltherapy