ESC HF 25: Kidney Function Trajectories Before and After HF Hospitalisation in HFrEF

ESC HF 25 - Real-world findings suggest kidney function decline could precede heart failure events by up to a year. Prof Nicolas Girerd (University Hospital of Nancy, Nancy, FR) discusses real-world findings from pooled trials EPHESUS, EMPHASIS-HF and BARCELONA. The study investigated if longitudinal changes in kidney function could help identify patients with HFrEF at a higher risk of hospitalization or death. Key findings revealed that kidney function decline significantly accelerated during the year before heart failure hospitalisation or death, and worsening NYHA class was more prominent in patients with multiple events. The study suggests that monitoring eGFR slopes could allow early detection of at-risk patients. Interview Questions: 1. What is the reasoning behind the trial? 2. What was the study design and patient population? 3. What are the key outcomes, and were there any surprising or unexpected results? 4. What are the underlying factors of these results? 5. How should these findings impact clinical practice? Recorded on-site at ESC HF in Belgrade, 2025. Editors: Jordan Rance, Yazmin Sadik Videographers: Tom Green and Mike Knight Support: This is an independent interview produced by Radcliffe CVRM. Visit Radcliffe Cardiology: https://www.radcliffecardiology.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook:   / radcliffecardiology   Follow us on X: https://x.com/radcliffeCARDIO