Cryo-EM17 lecture 06: Image refinement in 2D and 3D - Sjors Scheres

Sjors Scheres' group is interested in developing methods that allow visualisation of macromolecular machines in their multitude of natural states in order to understand how they work, as well as using these methods to determine the structures of unfolded amyloid proteins that are extracted from the brains of individuals with neurodegenerative diseases, like Alzheimer's and Pick's disease. Sjors is the main developer of RELION, a popular software package for cryo-EM structure determination. Read more about Sjors' work here: https://www2.mrc-lmb.cam.ac.uk/group-... Read more about RELION here: https://www2.mrc-lmb.cam.ac.uk/relion Download the lecture presentation here: https://www2.mrc-lmb.cam.ac.uk/downlo... You can find more videos from the 2017 LMB Cryo-EM course here:    • Electron Cryo-microscopy Course 2017   Other playlists you might be interested in: Electron Cryo-Microscopy Course 2014 -    • Electron Cryo-microscopy Course 2014   Electron Cryo-Microscopy -    • Electron Cryo-Microscopy   RELION -    • RELION   Research Highlights from our Structural Studies Division -    • Structural Studies Division   -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / lmbnews   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...