Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Join Dr. Mandy Janssen, Scientific Director of Characterization at NIS, to: Discover how cryo-TEM enables high-resolution visualization of individual LNPs in their near-native state. Analyze critical particle attributes - homogeneity, size distribution, morphology, lamellarity, structural integrity, payload distribution, and aggregation - all in one dataset. Harness automated image analysis tools for quantitative measurements of LNP size and morphology. Uncover particle-level differences during LNP formulation development, process optimization, and stability testing. Chapters 00:00 Speaker Introduction 01:37 Company Introduction 03:01 Cryogenic Electron Microscopy Technique 05:33 Cryo-TEM vs. Negative Stain TEM 07:45 Sample Preparation & Image Acquisition 09:02 LNP Imaging Challenges 10:45 Automated Size Distribution Analysis 11:47 Automated Particle Classification Analysis 13:14 LNP Characterization Case Study 19:21 Cryo-TEM vs. DLS 19:52 Cryo Electron Tomography 21:24 Applications of Cryo-TEM 23:03 Q&A Session