BEN BIKMAN L3 | EARLY CHECK FOR INSULIN RESISTANCE…. CHECK FREE FATTY ACIDS

http://www.DoctorsToTrust.com @doctorstotrust presents episode 3336 | Dr BEN BIKMAN East Asian and European Caucasian guys… Why is the Caucasian more likely to be fat but less likely to have T2D than Asian? -due to slow IR, begins in fat cells [most common point] -muscle and liver, so powerful at regulating blood glucose, if they become IR, you will have both elevated insulin and elevated blood glucose [this is different than typical fat cell becoming IR, but blood glucose stays low for years] What is the difference? size of the fat cells… Obesity is not just a matter of fat mass size -fat cell size matters more than size of total fat mass -this is why women, while fatter than men, are metabolically healthier -some ethnicities, and all women: under pressure to make more fat space, will make more fat cells -called hyperplasia [cells multiply] -many more small, fat cells, more anti-inflammatory Study showed that western men have fat cells 4 to 5 X smaller than counterparts in east… -Asians, due to pressure to store fat results in larger fat cells [hypertrophy] -as fat cells grow to near limit in size, becomes IR -and they push each other further from capillaries -and release pro-inflammatory cytokines Opportunity to identify IR at very first place in body… -the fat cell itself, by measuring free fatty acids coming from the IR fat cell -this is not part of a typical lipid profile lab test When insulin goes up, it promotes fat cell growth by -inhibiting lipolysis [breakdown of fat] -if insulin is up, expect FFA to be down Example: following a meal Counter example: when fasting: expect FFA up But in IR of fat cell: Both Are HIGH -called Adipo IR Index Men should be 6; Women 9 indicates IR at earliest state in slow IR |||||||||||||||||||||||||||||||| doctorstotrust.com benbikman.com insuliniq.com levelshealth.com Original Youtube:    • GLUCOSE METABOLISM: HbA1c, Insulin Resista...   This site will never use AI nor corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these short videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.