Predicting Progression of DCIS to Invasive Cancer
Dr Ettienne Myburgh, Panorama Centre for Surgical Oncology (www.pacso.co.za) explains our current understanding of biology of DCIS and how to guide treatment for patients. Part of the Cape Town Breast Cancer forum talks Feb 2023 0:47 Introduction 5:03 Why treat DCIS 5:52 Clinical Pathological Predictors 8:26 Van Nuys Prognostic Index 9:22 Nomogram to predict recurrence 9:55 Traditional view of how cancer develops 10:34 New models of understanding about progression to invasive cancer 12:25 Genetic evaluation of DCIS and invasive cancer 15:21 Spesific genetic changes 16:03 Importance of germline testing 17:04 Molecular Testing - MammaPrint or OncotypeDx 20:43 Micro-environment 24:15 Clinical decision making in DCIS 26:00 Prospective Analysis of VNPI 28:45 Online Nomogram for DCIS by MSK 29:12 Final Thoughts Corrections: 25:16 Please note Age in col 1 should be over 60
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