Explore neural circuits in 3D

Studying neural circuits is all about connectivity. So why cut up your sample? Check out these mesmerizing 3D data that scientists have generated with our sample processing techniques and SmartSPIM imaging on whole mouse brains. 🔬 🐭 🧠 0:00 - Retrograde viral labeling of an insula-BNST circuit identified by Dr. Joe Luchsinger et al. in a 2021 paper: https://www.nature.com/articles/s4146... 0:30 - Virally-expressed fluorescent reporters, alongside NeuN labeling, help PhD student Paige Hoffman visualize disruptions to neural function in neurodevelopmental disorders. 1:00 - tdTomato and nuclear staining reveal the architecture of cortical excitatory neural circuits in this data captured by Drs. Caroline Mrejen and Jing Zhou at the UCSF Weill Innovation Core. 1:30 - Retrograde viral labeling helps Drs. Kartik Pattabiraman and Dan Doyle, PhD visualize neural circuits in whole brains. 2:00 - Neurons and their projections are visible in exquisite detail in this video zooming in on the mouse hippocampus captured by Drs. Joe Luchsinger and Jose Maldonado.