Ketamine's pioneer missed something important

In this episode I sit down with the arylcyclohexylamine legend Dr. Edward F. Domino to discuss his pioneering research on ketamine, his subsequent research on NMDA antagonists, and his first encounter with a patient who reported antidepressant activity from using ketamine. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content: Amentara - https://www.amentara.com A source for Amanita muscaria, kanna, kava, akuamma, and all your other ethnobotanical needs. Use discount code "HAMILTON" for 22% off! MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS #sponsored #mudwtrpod Lucy Tobacco-Free Nicotine - https://www.lucy.co Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! _______________ 0:00 Introduction & context 2:45 The discovery of ketamine 8:30 Phencyclidine derivatives & Parke-Davis 14:15 First human administration of ketamine 19:30 The testicle compression experiment 23:45 Initial impressions & anesthetic potential 28:15 Collaboration with psychiatrists at Lafayette Clinic 32:00 Ketamine as a model for schizophrenia 36:30 The missed antidepressant discovery 42:15 The patient who knew better 46:45 Regret & listening to patients 51:00 FDA approval & antidepressant recognition 55:30 John C. Lilly & Marsha Moore 59:00 R-ketamine vs S-ketamine 63:45 The right-hand form & less dissociation 68:30 The Cal Stevens patent scandal 74:00 Cal Stevens the medicinal chemist 79:00 A missed opportunity to meet Cal Stevens 83:15 The endogenous ligand question 87:45 Complex mechanisms of ketamine action 92:00 Sigma receptors & research opportunities 96:30 R-ketamine as the future direction 101:00 Career advice & getting funded 105:30 The importance of permission from your boss 109:15 LSD-25 & other opportunities 112:45 Final reflections on legacy & family