Next Generation Sequencing - The Future of Medicine & Genomics?

Watch an ad-free and extended version of this video here: https://nebula.tv/videos/sophs-notes-... Next Generation Sequencing is a method that's revolutionised the way we study genetics. It's meant that the time it takes to work out someone's whole DNA sequence has plummeted over the last couple of decades, as has the cost. Many people, from scientists to investors, wax lyrical about its potential. But how does it work? And is it worth the hype? Feat. a new set, Poirot, and a reference Twitter told me to put in. Nebula version: https://watchnebula.com/videos/sophs-... Check out my Patreon:   / sophsnotes   Tweet me: @sophsnotes Insta me: @sophs_notes Music by Epidemic Sound: http://epidemicsound.com/creator Chapters: 0:00 What is NGS? 3:33 How NGS works 10:28 The Excitations 13:07 The Limitations 16:31 Catch an extended version of this video - link in bio! 18:38 Summary and goodbye 20:22 Outtakes ————————————— A huge thank you to my Patrons: 12tone Adam Dullinger Andrei Badoui Andrei Onea Brent Knudsen Chris Graham Colette Dan JMT Dhruv Singhal Few Thy Voice Filip Florin Godard Fredrik Samuelsson Geoffrey Shaffer Heather and Mike Interstellar sailboat João Lopes Justin Brown Katy and Daniel De La Torre Knowing Better Lydia Cockburn Mark Stradling Peter Kates Philip Philip Mooney Robbie the Space Raccoon ShutterCup (you'll get your shout out next time! :) I'd already recorded when you joined the team) Simon Law snylenna TechieSteve Terry Cox Tim van Mourik William Grunow ———————————————— References The basics and science of NGS https://www.ncbi.nlm.nih.gov/pmc/arti...    • NGS Data Analysis 101: RNA-Seq, WGS, and m...   https://www.yuzuki.org/next-generatio... https://genohub.com/next-generation-s... https://www.thermofisher.com/uk/en/ho... https://www.illumina.com/science/tech... Illumina sequencing by synthesis process (where fluorescent image is from)    • Overview of Illumina Sequencing by Synthes...   Podcast on NGS (feat. Microbiome man), and cost reduction of human genome https://www.technologynetworks.com/ge... Podcast on personalised genetic testing and data security questions https://www.technologynetworks.com/ca... Podcast on ethics of genetic testing https://www.technologynetworks.com/ge... Personalised medicine https://www.technologynetworks.com/ca... Moving beyond DNA sequencing for tumours https://www.nature.com/articles/d4158... European bias of current genomic info https://www.newscientist.com/article/... Genome UK (Nebula version) https://geneticalliance.org.uk/news-e... Extras not really discussed: Different NGS approaches for disease marker discovery https://f.hubspotusercontent40.net/hu... Liquid biopsieshttps://f.hubspotusercontent40.net/hu... Photo of Deepti https://www.sanger.ac.uk/person/gurda...