Through the Unlabeled Lens of Spatial Multi-Omics

This seminar was delivered on 1 June 2026. For more information: https://spds.sydney.edu.au/ Speaker: Dr Anthony A. Fung, Yale University Abstract: Sometimes it matters less what you look at, and more what you see. Common practices in clinical pathology often involve multiple histological stains on serial sections of tissue biopsy to obtain the highest diagnostic power, but this requires expertise, reagent costs, consumes tissue, risks deformation, and complicates co-registration, potentially missing rare microstructures. Now there is a major push for spatial multi-omics integration, but even adjacent tissue sections captured with different modalities decrease performance. Today’s seminar introduces a non-destructive label-free optical platform combining SRS, SHG, and TPF enables high-resolution molecular imaging to unravel the lipidomic, metabolic, and morphometric landscape of kidney disease, and how these data types can augment your modalities. About the speaker: Dr Anthony A. Fung is a T32 postdoctoral fellow in Professor Rong Fan’s group at Yale University. He received his PhD in Bioengineering at University of California San Diego from Professor Lingyan Shi’s group. Anthony has received several awards in the quantitative spatial biology field and is a collaborating investigator in both HuBMAP and SenNet consortia. His current work centers on the development and application of spatial multi-omics technologies in aging and immune senescence.