I Took an Experimental Sjögren's Drug for 2 Years (Dazodalibep) - Clinical Trial Update

THE 5TH VIRTUAL SJÖGREN'S SUMMIT IS NEXT WEEK: This is the room where clinicians, advocates, and fellow patients talk about exactly this: the pipeline, what is coming, and what it means for your care. The 5th Annual Virtual Sjögren's Summit is July 16 to 18, 2026, and registration is open now: https://sjogrenssummit.com Two years ago I sat down in an infusion chair and received an experimental drug for my own Sjögren's disease, because right now that is what the options look like for this condition. In this video I walk you through what two years in a Phase III Sjögren's clinical trial has actually been like: what the drug (Dazodalibep) is, how the trial was built, my honest results, and the pipeline of new Sjögren's treatments coming right behind it. Save this one and send it to anyone newly diagnosed who keeps asking what is being done about Sjögren's, because the honest answer is more hopeful than it has ever been. WHAT YOU'LL LEARN: Why there is still no FDA-approved drug for Sjögren's disease in the US, and why the medications we do use (hydroxychloroquine, rituximab) were borrowed from malaria, lupus, and cancer What Dazodalibep actually is: a fusion protein that blocks CD40 ligand, the messenger that keeps the B-cell and T-cell conversation in Sjögren's stuck in overdrive How the Phase III trial was built: double-blind and placebo-controlled, monthly versus every-three-month dosing, and what changed when I re-enrolled in the open-label extension My honest two-year experience: better baseline dryness, no more laryngitis or lost voice, improved energy and pain, plus the physician's caveat about why we still need the data (placebo effects are real) The Sjögren's pipeline right now: Dazodalibep, ianalumab, nipocalimab, efgartigimod, and telitacicept, each working at a different point in the immune system, so a first drug that does not fit you may not be the last FIND A CLINICAL TRIAL: Curious whether trial participation might be an option for you? Every clinical trial in the world is registered at https://clinicaltrials.gov, where you can search by condition, location, and zip code and see what is still recruiting. GO DEEPER WITH THE IC BLUEPRINT CHECKUP: If you want a structured map of your immune terrain to anchor the conversation with your own doctor, the IC Blueprint Checkup walks you through it: https://immuneconfident.com/checkup Note: The Checkup is an educational, consultative assessment and does not establish a prescribing Patient-Physician Relationship. Current ICI clinical patients: please do NOT purchase this. Message TERRAIN in your patient portal instead. READY TO WORK WITH DR. KARA DIRECTLY? If you're ready to work with someone who looks at the whole terrain, not just one piece, Dr. Kara offers telehealth appointments in WI, AL, OH, MO, TX, KY, WA, GA, IL, PA, FL, WV, CO, MD, IN, UT, MI, TN, NV, NJ, MT, NC, LA, ID, CT, or AZ. New patient care: https://www.drkarawada.com/new-patien... State not listed? Join the waitlist: https://www.drkarawada.com/waitlist JOIN THE COMMUNITY: ➡️ Join Dr. Kara's free Facebook group, the Becoming Immune Confident Community, for support and connection:   / crunchyallergist   ➡️ Join the Success with Sjogren's Sisterhood Facebook group for support and connection →   / successwithsjogrens   WATCH NEXT (Previous Videos) Sjögren's Disease Explained:    / @drkarawada   MCAS & Histamine Deep Dives:    / @drkarawada   Allergy & Immune Health:    / @drkarawada   CONNECT WITH DR. KARA Website → https://www.drkarawada.com/ YouTube →    / @drkarawada   LinkedIn →   / karawadamd   Instagram →   / immuneconfidentmd   Threads → https://www.threads.com/@immuneconfid... Podcast Instagram →   / becomingimmuneconfident   Facebook →   / karawadamd   Twitter →   / crunchyallergy   TikTok →   / immuneconfidentmd   CHAPTERS: 00:00 Two Years on Dazodalibep: My Personal Trial Update 00:53 Why This One Is Personal for Me 01:40 Why There's Still No Approved Sjögren's Drug 02:54 Why I Said Yes to the Trial 03:37 What Dazodalibep Is and How It Works 04:40 Inside the Phase III Trial Design 05:46 The New Every 3 Month Dosing Change 06:27 My Honest Results After Two Years 08:37 This Is Not a Cure, and That's Okay 09:24 Why I Push for Seronegative Patients 10:04 The Sjögren's Drug Pipeline Right Now 11:12 How to Find a Clinical Trial and Join the Summit